October 1 - 3,  2008      Rotterdam      The Netherlands

2008

Programme

Wednesday       October 1, 2008

11.30                      REGISTRATION


13.30  Welcome


           Jan Trapman (Erasmus MC, Rotterdam, The Netherlands)




                       Session 1: Novel Technologies


13.45  Keynote speaker


           Michael Mancini (Baylor College of Medicine, Houston, USA)


                  Nuclear receptor functional analysis by high throughput
                  systems biology


14.20  René Houtman (Pamgene, ‘s Hertogenbosch, The Netherlands)


                  MARCoNI: receiving the signals of nuclear receptor-coregulator
                  interactions


14.40  Ian Mills (University of Cambridge, UK)


                  Androgen target genes


15.00  Martin van Royen (Erasmus MC, Rotterdam, The Netherlands)


                  A two-step model for androgen receptor domain interactions
                  in living cells


15.15 - 15.45           BREAK + POSTER VIEWING



15.45  Fahri Saatcioglu (University of Oslo, Norway)


                Ligand-specific dynamics of the androgen receptor at its
                response elements in living cells


16.05  Cor Kuil (Organon-Schering Plough, Oss, The Netherlands)


                Drug discovery on steroid hormone receptors


16.25  Nicola Clegg (Memorial Sloan Kettering Cancer Center, New York, USA)


                Development of androgen receptor antagonists with
                a novel mechanism of action


16.40  Keynote speaker


           Gordon Hager (NIH,Bethesda, USA)


                Genome wide nuclear receptor/chromatin interactions


17.15                        FINISH


18.00 – 19.30          RECEPTION


Thursday       October 2, 2008, morning programme

                       Session 2: Transcriptional Control by Androgen Receptors I


09.00  Keynote speaker


           Wouter de Laat (Erasmus MC, Rotterdam, The Netherlands)


                 Inter-chromosomal gene regulation in the
                 mammalian cell nucleus


09.35  Frank Claessens (University of Leuven, Belgium)


                 The colorful world of androgen response elements


09.55  Roland Schüle (Klinikum der Universität Freiburg, Germany)


                 Androgen action and histone modifications in prostate cancer


10.15  Nan Wang (University of Newcastle upon Tyne, UK)


                 Functional characterization of histone methyltransferase
                 SET9 in prostate cancer cells


10.30 – 11.00          BREAK + POSTER VIEWING






11.00  Bernard Haendler (Bayer-Schering Pharma AG,Berlin, Germany)


                  Functional consequences of androgen receptor acetylation


11.20  Craig Robson (University of Newcastle upon Tyne, UK)


                  Properties and expression of AR coregulators


11.40  Hannelore Heemers (Mayo Clinic, Rochester, MN, USA)


                  Coregulators in prostate cancer: regulating the regulators


11.55 – 14.30          LUNCH + POSTER SESSION


Thursday       October 2, 2008, afternoon programme

                       Session 3: Transcriptional Control by Androgen Receptors II


14.30  Keynote speaker


           Marc Timmers (UMC, Utrecht, The Netherlands)


                   Dynamic regulation of core promoter activity


15.05  Olli Jänne (University of Helsinki, Finland)


                  Structural and functional analysis of androgen receptor
                   on chromatin


15.25  Guido Jenster (Erasmus MC, Rotterdam, The Netherlands)


                   Gene expression profiling of the human prostate zones


15.45  Axel Thomson (MRC, Edinburgh, UK)


                  Androgens, Notch signaling and stromal survival
                  during prostate development


16.00 – 16.30          BREAK + POSTER VIEWING






16.30  Charlotte Bevan (Imperial College, London, UK)


                  Mechanisms of androgen receptor repression


16.50  Jorma Palvimo (University of Kuopio, Finland)


                 Androgens regulate ETS-like transcription factor 4
                 in prostate cancer cells


17.05  Keynote speaker


           Bas van Steensel (NKI, Amsterdam, The Netherlands)


                   Genome-wide views of chromatin structure and function


17.40                        POSTER AWARD CEREMONY


17.50                        FINISH


20.00                        CONGRESS DINNER


Friday       October 3, 2008

                       Session 4: Molecular Basis of Prostate Cancer


09.00  Keynote speaker


           Fritz Schröder (Erasmus MC, Rotterdam, The Netherlands)


                  Early detection of prostate cancer in 2008


09.35  Keynote speaker


           Steven Balk (Harvard Medical School, Boston, USA)


                  AR, the cell cycle and prostate cancer


10.10  Frank de Jong (Erasmus MC, Rotterdam, The Netherlands)


                  Intraprostatic androgens and expression of androgen
                  biosynthetic enzymes


10.30  Elahe Mostaghel (Fred Hutchinson Cancer Research Center,
                                                                                                                              Seattle, USA)


                Androgen levels and steroidogenic enzyme expression in
                castration resistant prostate cancer metastases


10.45 – 11.15          BREAK





11.15  Ralf Hoffmann (Philips Research, Eindhoven, The Netherlands)


                  Phosphodiesterases in prostate cancer


11.35  Norman Maitland (University of York, UK)


                  The challenge of targeting stem cells in prostate cancer


11.55  Colin Cooper (Institute of Cancer Research, Sutton, UK)


                  Fusion transcripts in prostate cancer


12.15  Delila Gasi (Erasmus MC, Rotterdam, The Netherlands)


                  A small region on chromosome 14 is a hot-spot for ETV1
                  rearrangements in prostate cancer


12.30  Keynote speaker


           James Dalton (GTx, Inc, Memphis, USA)


                Pharmacology of Selective Androgen Receptor
                Modulators (SARMs)


13.05                        CLOSURE


Contact: m.a.vandenakker@erasmusmc.nl

Androgens 2008

Erasmus MC, Rotterdam, The Netherlands